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The film tells a story of Brian Finch, a 28- year-old musician who is bored and exhausted by everything arround him. He is introduced to a miracle drug called NZT-48 that can give him ability to use total power of his brain. 12 hours later when using the drug, Brian is smarter and he can analyse as well as handle problems faster. After taking a second drug to be agaist NZT’s deadly effects, Brian begins to help FBI agent Rebecca Harris by using his special ability.